Antimicrobial polypeptides and their uses

Details Antimicrobial polypeptides and their uses Antimicrobial polypeptides and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01) A01N 63/00 (2006.01) C07K 1/16 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/04 (2006.01) C12N 7/01 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/80 (2006.01) C12N 15/81 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2444683

The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the invention include polypeptides that possess antimicrobial properties, particularly fungicidal properties, and the encoding nucleic acid molecules. The polypeptides of the invention are isolated from the hemolymph and fat bodies of insect larvae induced by injection of plant pathogenic fungi. Further provided are plant cells, plants, an seed thereof, transformed with the nucleic acid mole cules of the invention so as to confer disease resistance on the plant.

L'invention concerne des procédés et des compositions agissant sur des agents pathogènes microbiens et améliorant la résistance aux maladies dues à des agents pathogènes, notamment chez les plantes. Les compositions selon l'invention comprennent des polypeptides présentant des propriétés antimicrobiennes, notamment des propriétés fongicides, et les molécules d'acides nucléiques codant pour ces polypeptides. Les polypeptides selon l'invention sont isolés de l'hémolymphe et des corps adipeux de larves d'insectes, induits par l'injection de champignons pathogènes de plantes. L'invention concerne également des cellules de plantes, des plantes et des graines de ces plantes, transformées par les molécules d'acides nucléiques selon l'invention afin de conférer à la plante une résistance aux maladies.

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