Antimicrobial quinolonyl lactams

Details Antimicrobial quinolonyl lactams Antimicrobial quinolonyl lactams

C - Chemistry, Metallurgy

07

D

167/100, 260/104

C07D 463/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 477/10 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01) C07D 501/46 (2006.01) C07D 503/00 (2006.01) C07D 505/00 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2001205

Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked, by a non-ester linking moiety, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula; Image wherein (1) R3, R4, and R5, together with bonds "a" and "b", form any of a variety of lactam-containing moieties similar to those known in the art to have antimicrobial activity; (2) A, R6, R7, and R8 form any of a variety of quinolone or naphthyridine structures similar to those known in the art to have antimicrobial activity; and (3) Y, together with R5, form a variety of non-ester linking moieties between the lactam-containing moiety and the quinolone moiety.

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