Antimicrobial quinolonyl lactams

Details Antimicrobial quinolonyl lactams Antimicrobial quinolonyl lactams

C - Chemistry, Metallurgy

07

D

C07D 501/56 (2006.01) C07D 417/14 (2006.01) C07D 463/00 (2006.01) C07D 477/00 (2006.01) C07D 477/14 (2006.01) C07D 477/20 (2006.01) C07D 499/00 (2006.01) C07D 499/88 (2006.01) C07D 501/00 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01) C07D 498/053 (1990.01)

Patent

CA 2078444

2078444 9116327 PCTABS00007 Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and (2) R6 is part of a linking moiety, linking hte quinolone moiety to a lactam-containing moiety having formula (II), wherein (3) R10, R11, R12, R13, and R14, together with bonds ''a'' and ''b'', form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and (4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, ester, thioester, amide, and hydrazide groups.

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