Antimicrobial sulfonamide derivatives of lipopeptide...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/64 (2006.01) A61K 38/12 (2006.01) A61P 31/00 (2006.01) C07K 1/14 (2006.01) C07K 7/08 (2006.01) C07K 7/56 (2006.01) C07K 9/00 (2006.01) C07K 11/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2450372

The present invention provides antimicrobial sulfonamide derivatives of lipopeptide antibiotics, pharmaceutical compositions of antimicrobial sulfonamide derivatives, methods for making antimicrobial sulfonamide derivatives, methods for inhibiting microbial growth with antimicrobial sulfonamide derivatives and methods for treating or preventing microbial infections in a subject with antimicrobial sulfonamide derivatives. Antimicrobial sulfonamide derivatives are generally an amino core antibiotic that has been further modified with a lipophilic sulfonyl group.

L'invention concerne des dérivés sulfonamide antimicrobiens d'antibiotiques lipopeptidiques, des compositions pharmaceutiques de dérivés sulfonamide antimicrobiens, des procédés de production de dérivés sulfonamide antimicrobiens, des procédés d'inhibition de croissance microbienne au moyen de dérivés sulfonamide antimicrobiens, et des méthodes de traitement et de prévention d'infections microbiennes chez un sujet au moyen des dérivés sulfonamide antimicrobiens. Les dérivés sulfonamide antimicrobiens sont généralement un antibiotique noyau aminé ayant subi une modification supplémentaire au moyen d'un groupe sulfonyle lipophilique.

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