Antimicrobial triazole derivatives

Details Antimicrobial triazole derivatives Antimicrobial triazole derivatives

C - Chemistry, Metallurgy

07

D

260/304.7

C07D 405/06 (2006.01) A01N 43/653 (2006.01) C07D 249/04 (2006.01) C07D 317/16 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1137089

ABSTRACT Novel 1H-1,2,4-triazole derivative which have the formula Image (I) and the phytopharmaceutically acceptable acid addition salts, metal salt complexes and stereochemically isomeric forms there- of, wherein R1, R2 and R3 are each independently selected from the group consisting of hydrogen, lower alkyl, lower alkyloxy, halo, nitro, cyano and trifluoromethyl; n is the integer 0 or 1; x is a member selected from the group consisting of O and S; and R4 is a member selected from the group consisting of alkyl, mono-, di- and trihalo-alkyl, lower alkyloxy-lower alkyl, mono-, di- and trihalo-lower alkyloxy-lower alkyl, lower alkneyl, 2- propynyl, 3-halo-2-propynyl, cycloalkyl, aryl, aryl-lower alkyl and aryl-lower alkenyl, wherein said aryl is selected from the group consisting of phenyl and substituted phenyl said sub- stituted phenyl having from 1 to 3 substituents each independently selected from the group consising of lower alkyl, lower alkyl- oxy, halo, nitro, cyano, trifluoromethyl, phenyl, phenyloxy and phenylthio, provided that only one of the substituents may be selected from the group consisting of phenyl, phenyloxy and phenylthio, and wherein said phenyl and the phenyl part of said phenoxy and phenylthio are optionally substituted with up to three substituents each independently selected from the group consisting of lower alkyl, lower alkyloxy, halo nitro, cyano and trifluoromethyl, provided that when n is 0 then R4 is other than alkyl. These compounds posses advantageous antimicrobial spectrum which renders them useful for protection of crops without causing undesired side reactions.

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