Antimitotic rhizoxin derivatives of burkholderia rhizoxina,...

Details Antimitotic rhizoxin derivatives of burkholderia rhizoxina,... Antimitotic rhizoxin derivatives of burkholderia rhizoxina,...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/422 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2624958

The invention concerns novel secondary metabolites of the Burkholderia rhizoxina endosymbiont, a method for isolating said compounds from cultures of the bacteria and the use of said substances. The invention aims at providing novel rhixozin derivatives with antimitotic effect. Therefor, the following substances (1-4) are isolated, said substances exhibiting potent antifungal, cytotoxic and antiproliferative properties.

L'invention concerne quatre nouveaux métabolites secondaires de l'endosymbiote Burkholderia rhizoxina, un procédé d'isolation de ces composés à partir de cultures de la bactérie et l'utilisation de ces substances. L'objectif de cette invention est de fournir de nouveaux dérivés de rhizoxine à effet antimitotique. A cet effet, les substances suivantes (1-4) sont isolées, lesquelles substances possèdent de puissantes propriétés antifongiques, cytotoxiques et antiprolifératives.

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