Antineoplastic cocoa extracts and methods for making and...

A - Human Necessities – 61 – K

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A61K 31/353 (2006.01) A61K 36/185 (2006.01) A61P 35/00 (2006.01) C07D 311/62 (2006.01) C09K 15/34 (2006.01) A61K 31/35 (2006.01) C07D 493/18 (2006.01)

Patent

CA 2201310

Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use cf the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.

L'invention concerne des extraits de cacao, tels que des polyphénols ou des procyanidines, des procédés servant à préparer ces extraits, ainsi que leurs utilisations, particulièrement en tant qu'agents antinéoplasiques et qu'antioxydants. Elle concerne également des compositions antinéoplasiques contenant des polyphénols ou des procyanidines de cacao, ainsi que des procédés servant à traiter des patients au moyen de ces compositions. Elle concerne, de plus, un kit de traitement d'un patient au moyen d'un agent antinéoplasique contenant des polyphénols ou des procyanidines de cacao, ainsi qu'une composition lyophilisée antinéoplasique contenant des polyphénols ou des procyanidines de cacao. Elle concerne enfin l'utilisation des extraits précités dans des compositions antioxydantes, préservatrices et inhibant la topiosomérase ainsi que dans des procédés associés.

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