Antineoplastic combinations of 4-anilino-3-cyanoquinolines...

A - Human Necessities – 61 – K

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Details

A61K 31/517 (2006.01) A61K 31/7068 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2730715

A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272, SKI-606, EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens, kits, and methods for treatment of neoplasm, including breast cancer including metastatic breast cancer, and lung cancer, using this combination, optionally in combination with other anti-neoplastic agents, or immune modulators are also described.

La présente invention concerne une combinaison dun composé de 4-anilino-3-cyanoquinoléine (par exemple, HKI-272, SKI-606, EKB-569) et dun composé de capécitabine dans le traitement dune néoplasie. La présente invention concerne en outre des régimes, kits et procédés pour le traitement dune néoplasie, comprenant le cancer du sein, y compris le cancer du sein métastasique, et le cancer du poumon, en utilisant cette combinaison, éventuellement en combinaison avec dautres agents antinéoplasiques ou des immunomodulateurs.

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