C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/22 (2006.01) C07C 237/30 (2006.01) C07C 275/18 (2006.01) C07C 275/22 (2006.01) C07C 275/36 (2006.01) C07C 313/06 (2006.01) C07C 327/44 (2006.01) C07D 207/36 (2006.01) C07D 213/82 (2006.01) C07D 215/18 (2006.01) C07D 233/54 (2006.01) C07D 235/14 (2006.01) C07D 239/36 (2006.01) C07D 239/42 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2607298
The invention relates to chemical compounds which are obtained by means of in silico molecular modelling and which have a structure that can be used to block phosphorylation by interacting said compounds with the phosphorylation domain or the environment thereof in the substrates of the Casein Kinase II enzyme. The invention also relates to pharmaceutical compositions that contain said compounds and to the use thereof in the preparation of medicaments for the treatment of diseases associated with neoplastic processes.
L'invention concerne des composés chimiques obtenus par modélisation moléculaire dans de la silice, dont la structure permet le blocage de la phosphorylation par l'interaction desdits composés avec le domaine de phosphorylation ou son environnement dans les substrats de l'enzyme caséine kinase 2. L'invention concerne également les compositions pharmaceutiques contenant lesdits composés ainsi que leur utilisation dans la préparation de médicaments destinés au traitement de maladies liées à des processus néoplasiques.
Acevedo Castro Boris Ernesto
de La Nuez Veulens Ania
Mazola Reyes Yuliet
Musacchio Lasa Alexis
Perea Rodriguez Silvio Ernesto
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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