Antineoplastic cyclolignan derivatives

Details Antineoplastic cyclolignan derivatives Antineoplastic cyclolignan derivatives

C - Chemistry, Metallurgy

07

D

C07D 317/70 (2006.01) A61K 31/36 (2006.01)

Patent

CA 2162761

Antineoplastic cyclolignan derivatives are of formula (I): (see formula I) in which Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group =CH- or an alkylmethine group =C(alkyl)-; Y is a hydrogen atom or an alkyl, alkenyl, (poly)haloalkyl, aryl, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino, (poly)haloalkylamino, arylamino, acyl or acetamido group, or the group Y is absent; Z is an alkyl, hydroxyalkyl, acyl, carboxy, alkoxycarbonyl or aryloxycarbonyl group; and the dotted lines indicate one double bond located at position .DELTA.7-8 or .DELTA.8-8'.

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