Antineoplastic derivatives of 4-oxo-l, 4-dihydro-quinolin?,...

Details Antineoplastic derivatives of 4-oxo-l, 4-dihydro-quinolin?,... Antineoplastic derivatives of 4-oxo-l, 4-dihydro-quinolin?,...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4375 (2006.01) A61K 31/4709 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 213/40 (2006.01) C07D 213/82 (2006.01) C07D 215/56 (2006.01) C07D 401/14 (2006.01) C07D 407/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2730071

The invention relates to antineoplastic compounds of formula (I) where: - R1 is a (C3-C7)cycloalkyl or (C1-C6)alkyl group optionally substituted with NRaNb; - A is NR2N3; - B is -NR4R5 or OR6; R6 is H or a (C1-C4)alkyl group; - Z is N or CH, and Z is N or CH if Z is N and CH if Z is CH; - R7 is H or a (C1-C4) alkyl group; - L is a CH=CH-, -CH2CH2-, -CH2CH[NHC(=O)O(C1-C4)alkyl]], or (CH2)n-Y- group (n=1-4, and y = O or NR8, with R8 being H or a (C1-C4)alkyl group); - Ar is a group chosen from formula (II).

L'invention est relative à des composés anticancéreux de formule (1):dans laquelle : .cndot. R1 représente un groupe (C3-C7)cycloalkyle ou (C1-C6)alkyle éventuellement substitué par -NR a R b; .cndot. A représente - NR2R3; .cndot. B représente -NR4R5 ou -OR6; .cndot. R6 représente H ou un groupe (C1-C4)alkyle; .cndot. Z représente N ou CH et Z' représente N ou CH si Z représente N et CH si Z représente CH; .cndot. R7 représente H ou un groupe (C1-C4)alkyle; .cndot. L représente un groupe -CH=CH- , -CH2CH2-, -CH2CH[NHC(=O)O(C1-C4)alkyle)] ou - (CH2)n-Y- (n=1-4 et Y = O ou NR8 avec R8 représente H ou un groupe (C1- C4)alkyle); .cndot. Ar représente un groupe choisi parmi :Formula (II).

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