Antineoplastic heteronaphthoquinones

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 5/078 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) A61K 38/05 (2006.01) C07D 311/76 (2006.01) C07D 311/92 (2006.01) C07D 335/08 (2006.01) C07D 405/12 (2006.01) C07D 491/052 (2006.01) C07D 495/04 (2006.01) C07F 9/547 (2006.01) C07H 15/252 (2006.01) C07H 17/00 (2006.01) C07H 17/04 (2006.01)

Patent

CA 2146548

Tricyclic heteronaphthoquinone derivatives, that have antineoplastic activity, are disclosed, together with processes for their synthesis. Some of these anti-neoplastics compounds have a saccharide moiety. Some members of this structurally distinct group exhibit activity against multiple drug resistant cancer cells.

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