Antineutrophilia agent using 3(2h)-pyridazinone compounds

Details Antineutrophilia agent using 3(2h)-pyridazinone compounds Antineutrophilia agent using 3(2h)-pyridazinone compounds

A - Human Necessities

61

K

A61K 31/501 (2006.01) A61P 7/00 (2006.01) A61P 11/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2549672

To provide an antineutrophilia agent effective for treatment of development and progress of acute infections, collagen diseases (chronic rheumatoid arthritis, Wegener's granulomatosis and Behcet's disease), chronic obstructive pulmonary disease (COPD), chronic bronchitis, pulmonary emphysema, small airway disease, gout, Cushing's syndrome, myelofibrosis, neoplastic neutrophilia, polycythemia vera and diseases caused by administration of steroid drugs. An antineutrophilia agent containing a 3(2H)--pyridazinone compound represented by the formula (I) or a pharmaceutically acceptable salt thereof [wherein each of R1, R2 and R3 is independently a hydrogen atom or a C1-6 alkyl group, X is a halogen atom, cyano or a hydrogen atom, Y is a halogen atom, trifluoromethyl or a hydrogen atom, and A is a C1-8 alkylene which may be substituted with a hydroxyl group]. (see formula I)

La présente invention concerne un inhibiteur de neutrophilie permettant de traiter efficacement la fréquence ou la progression de maladies infectieuses aiguës, de maladies du collagène, de la broncho-pneumopathie chronique obstructive (BPCO), de la bronchite chronique, de l'emphysème pulmonaire, des maladies des petites voies respiratoires, de la goutte, du syndrome de Cushing, de la myélofibrose, de la neutrophilie tumorale, de la polycythémie vraie, et des états pathologiques observés, par exemple, lors de l'administration d'agents stéroïdes. Cet inhibiteur de neutrophilie contient un composé de 3(2H)-pyridazinone représenté par la formule (I) ou un sel pharmacologiquement acceptable de ce composé. [Dans cette formule, R<sp>1</sp>, R<sp>2</sp> et R<sp>3</sp> représentent chacun indépendamment hydrogène ou alkyle C<sb>1-6</sb>; X représente halogéno, cyano, ou hydrogène; Y représente halogéno, trifluorométhyle ou hydrogène; et A représente éventuellement alkylène C<sb>1-8</sb> hydroxylé.]

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