C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/179, 260/489
C07C 317/24 (2006.01) A61K 31/22 (2006.01) C07C 271/22 (2006.01) C07C 323/56 (2006.01) C07D 207/16 (2006.01)
Patent
CA 1293253
A B S T R A C T Mono- or bis-complex esters or ethers of a phenol derivative of the formula MU-A-X-R1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydxoxyphenyl-hydroxynaphthyl; hydroxyph nyl-hydroxyindanyl, hydroxyphenyl-hydroxy- benæothienyl or di-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R1 is hydrogen, or alkyl, alkenyl, cycloalkyl, halogenoalkyl, aryl or arylalkyl, or R1 is joined to R2, and wherein X is -CONR2-, -CSNR2-, NR12CO-, -NR12CS-, -NR12CONR2-, Image , -SO2NR2- or -CO-, or, when is not hydrogen, is -NR12COO-, -S-, -SO- or -SO2- wherein R2 is hydrogen or alkyl, or Rl and R2 together form alkylene; wherein R12 is hydrogen or alkyl, and wherein R22 is hydrogen, cyano or nitro; or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.
480141
Edwards Philip Neil
Tait Brian Steele
Imperial Chemical Industries Plc
Smart & Biggar
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