Antioxidant and fe2+ chelating properties of herbal extracts

Details Antioxidant and fe2+ chelating properties of herbal extracts Antioxidant and fe2+ chelating properties of herbal extracts

A - Human Necessities

61

K

A61K 36/258 (2006.01) A61K 36/16 (2006.01) A61K 36/38 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 39/04 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2625204

The present invention is directed to antioxidative and antiproliferative agents containing North American ginseng (proprietary extract HTlOOl) alone or in combination with Ginkgo biloba (GB), Saint John's Wort (SJW), ginkgolides, flavonoids, ginsenosides, hypericin, and/or hyperforin. The antioxidative and antiproliferative agents according to the present invention show significant inhibition of Fe2+-catalyzed lipid peroxidation and Fe2+ chelation activity, the ability to scavenge hydroxyl free radicals, the ability to reduce neuroblastoma cell numbers, and/or the ability to promote neurite outgrowth. These effects are consistent with the behavior of Fe2+ chelators and the variance in both type and magnitude of effects exerted by the chemical components suggests a synergistic mechanism of action.

L'invention concerne des agents antioxydants et antiprolifératifs contenant du ginseng d'Amérique du nord (extrait propriétaire HT1001) seul ou en combinaison avec du Ginkgo biloba (GB), du millepertuis (SJW), des ginkgolides, des flavonoïdes, des ginsenosides, de l'hypericine, et/ou de l'hyperforine. Les agents antioxydants et antiprolifératifs de l'invention présentent également une inhibition importante de péroxydation du lipide catalysé Fe2+/- et de l'activité de chélation Fe2+, une capacité à piéger des radicaux libres d'hydroxy, la capacité à réduire le nombre de cellules neuroblastomes, et/ou la capacité à promouvoir l'excroissance des neurites. Ces effets sont compatibles avec le comportement des chélateurs Fe2+ et la variance à la fois dans le type et la magnitude des effets exercés par les composants chimiques suggèrent un mécanisme d'action synergique.

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