Antioxidant composition and method of treating diseases...

A - Human Necessities – 61 – K

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A61K 36/82 (2006.01) A61K 31/352 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61K 31/4415 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/56 (2006.01) A61K 31/7076 (2006.01) A61P 25/28 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2339004

Damage to cells, tissue and other body parts in a mammalian host may be treated by using hypoxanthine and in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, neurodegenerative disease and damage caused by radiation therapy, high oxygen tension, and chemotherapy.

L'invention concerne le traitement des atteintes des cellules, des tissus et d'autres parties de l'organisme d'un mammifère par l'hypoxanthine combinée à au moins un modificateur biologique, ce dernier pouvant être un piégeur de radicaux libres ou un antimétabolite. Le modificateur biologique est de préférence l'acide urique, la sulfoximine de buthionine, la vitamine C, l'aspirine ou l'acide nordihydroguaïarétique. Une telle combinaison peut être utilisée pour traiter par exemple les cancers, les maladies infectieuses, les maladies neurodégénératives et les dommages résultant de la radiothérapie, d'une haute tension en oxygène et de la chimiothérapie.

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