Antioxidant compounds

Details Antioxidant compounds Antioxidant compounds

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/138 (2006.01)

Patent

CA 2253230

A new use of halogenated triphenylethylene derivatives for lowering levels of serum lipid peroxides and for the prevention or treatment of oxidative tissue damage induced by lipid peroxidation is disclosed. The new use includes the prevention or treatment of atherosclerosis, ischemic injury, psoriasis, inflammatory diseases, such as inflammatory bowel disease, or cardiovascular disorders, such as coronary heart disease, cardiac ischemic injury and post-ischemic cardiac arrhythmias, or the treatment of AIDS.

Cette invention se rapporte à une nouvelle utilisation de dérivés de triphényléthylène halogéniques pour abaisser le niveau de peroxydes lipidiques sériques et pour prévenir ou traiter les dommages tissulaires oxydatifs induits par une peroxydation lipidique. Cette nouvelle utilisation concerne la prévention ou le traitement de l'athérosclérose, des lésions ischémiques, du psoriasis, des maladies inflammatoires, telles que les affections intestinales inflammatoires, ou les troubles cardio-vasculaires, tels que les maladies cardiaques des coronaires, les lésions ischémiques cardiaques et les arythmies cardiaques post-ischémiques, ou le traitement du SIDA.

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