Antioxidant enhancement of therapy for hyperproliferative...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01)

Patent

CA 2294247

A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant. The invention also includes a method to decrease the toxicity to an antineoplastic agent or increase the therapeutic index of an antineoplastic agent administered for the treatment of a solid growth of abnormally proliferating cells, comprising administering an antioxidant prior to, with, or following the antineoplastic treatment.

L'invention concerne un procédé pour améliorer l'activité cytotoxique d'un médicament antinéoplasique, ce procédé consistant à administrer à l'hôte qui présente une prolifération cellulaire anormale une quantité efficace de ce médicament en combinaison avec un antioxydant présent dans des quantités efficaces pour augmenter la cytotoxicité. L'invention se rapporte également à un procédé pour diminuer la toxicité d'un agent antinéoplasique ou pour augmenter l'indice thérapeutique d'un agent néoplasique administré à des fins de traitement d'une forte croissance de cellules proliférant de façon anormale. Le procédé consiste à administrer un antioxydant avant, pendant ou après le traitement antinéoplasique.

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