Antioxidant nitroxides and nitrones as therapeutic agents

Details Antioxidant nitroxides and nitrones as therapeutic agents Antioxidant nitroxides and nitrones as therapeutic agents

C - Chemistry, Metallurgy

07

C

C07C 259/00 (2006.01) C07C 251/32 (2006.01) C07C 291/02 (2006.01) C07C 291/06 (2006.01)

Patent

CA 2442798

The invention provides novel adamantane compounds having one of the following formulas wherein R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate; R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R9-R14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to the use of compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmatically acceptable carrier.

L'invention concerne de nouveaux composés adamantane représentés par une des formules suivantes (I), (II), (III) où R1 et R3 représentent H, OH, alkyle, cycloalkyle, amino ou aryle et peuvent être identiques ou différents ; R2 représente H, NH2, alkyle, OH, COOH, amino, amide ou carbamate ; R4-R8 représentent H, OH, NH2, alkyle, OH, COOH, ester, amino, amide ou alkyloxy et peuvent être identiques ou différents ; R9-R14 représentent H, alkyle ou phényle et peuvent être identiques ou différents, et où, lorsqu'un élément quelconque parmi R1-R8 représente amino, les composés sont les bases libres et leurs sels d'addition acides. L'invention concerne également l'utilisation de compositions et de procédés visant à traiter et/ou à prévenir des troubles neurologiques et inflammatoires chez un patient par l'administration d'une quantité thérapeutiquement efficace de composés de formule (I), (II) ou (III) et un excipient pharmaceutiquement acceptable.

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