C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2238662
Antioxidant Responsive Element The present invention relates, in general, to antioxidant responsive elements (AREs). In particular, the present invention relates to a DNA construct comprising an ARE having the DNA sequence 5'-RGR AC NNN GCT-3' (SEQ ID NO :1 ) operably linked to a heterologous protein coding sequence; cells and non-human organisms comprising the DNA construct; a method of screening for a compound that increases transcription of an mRNA regulated by an antioxidant responsive element; and a purified compound that binds to an antioxidant responsive element.
L'invention concerne, en général, des éléments sensibles aux antioxydants (ARE). En particulier, elle a trait à un construit d'ADN comprenant un ARE ayant la séquence d'ADN 5'-RGR AC NNN GCT-3' (SEQ ID NO :1) liée fonctionnellement à une séquence codante d'une protéine hétérologue; des cellules et des organismes non humains comprenant l'ADN synthétique; une méthode de criblage d'un composé qui accroît la transcription d'un ARNm contrôlé par un élément sensible aux antioxydants; et un composé purifié qui se lie à un élément sensible aux antioxydants.
Queen's University At Kingston
Steeg Carol Miernicki
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