Antiparasitic agents

Details Antiparasitic agents Antiparasitic agents

C - Chemistry, Metallurgy

07

D

167/202, 260/233

C07D 495/22 (2006.01) A01N 43/90 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01)

Patent

CA 1330795

Abstract Antiparasitics comprising Avermectin derivatives of formula (I): Image (I) wherein the broken line between the 22-23 position represents an optional double bond and wherein either R1 is H or OH and the double bond is absent, or the double bond is present and R1 is absent, R2 is a C1-C6 alkyl group substituted by one oxo group or by a single oxygen atom on two adjacent carbon atoms to form an oxirane ring, or R2 is a C1-C5 alkyl group substituted by a (C1-C6 alkoxy) carbonyl group, said substituents on R2 being attached to either or both a terminal carbon atom and a carbon atom adjacent to a terminal carbon atom of R2, and R3 is H or CH3, or, when R2 is substituted by oxo, a (C1-C4 alkyl) acetal or ketal derivative thereof.

596834

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