Antiparasitic artemisinin derivatives (endoperoxides)

Details Antiparasitic artemisinin derivatives (endoperoxides) Antiparasitic artemisinin derivatives (endoperoxides)

C - Chemistry, Metallurgy

07

D

C07D 493/18 (2006.01) A61K 31/335 (2006.01) A61K 31/35 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01) C07D 265/00 (2006.01) C07D 307/00 (2006.01)

Patent

CA 2337119

This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.

La présente invention se rapporte à l'utilisation de certains dérivés substitués en C10 de l'artémisinine répondant à la formule (I) dans le traitement curatif et/ou préventif de maladies due s à l'infection par un parasite, à certains dérivés substitués en C10 de l'artémisinine, à leurs procédés de préparation et à des compositions pharmaceutiques contenant ces dérivés substitués en C10. Les composés de l'invention s'avèrent particulièrement efficaces dans le traitement de la malaria, de l'infection à Néospora et de la coccidiose.

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