Antiparasitic compositions

Details Antiparasitic compositions Antiparasitic compositions

A - Human Necessities

01

N

A01N 57/16 (2006.01) A01N 37/44 (2006.01) A01N 43/48 (2006.01) A01N 43/78 (2006.01) A01N 43/90 (2006.01) A61K 9/16 (2006.01) A61K 31/395 (2006.01) A61K 31/66 (2006.01) A61K 31/70 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2163455

This invention concerns the delivery of anti-parasitic agents to ruminant animals. More particularly, the invention concerns delivery of such agents in a controlled manner to enable the agent to have maximum effect on the parasite for longer times than is possible with conventional formulations. The compositions of the invention comprises a benzimidazole, macrocyclic lactone, organophosphate, salicylanilide/substituted phenol, tetramisole or pyrimidine anti-parasitic agent dispersed in a medium the solubility characteristics of which are such as to ensure that, following oral administration, controlled amounts of the anti-parasitic agent become available to the parasite, either directly or by absorption into the ruminant blood plasma, during passage of the composition through the rumen, the abomasum and the intestine.

L'invention concerne la diffusion d'agents anti-parasitaires chez des ruminants et, plus particulièrement, leur diffusion modulée de façon que ces agents exercent un effet maximum sur un parasite plus longtemps que ce n'est possible avec des formulations conventionnelles. La composition inventée comprend un agent anti-parasitaire à base de benzimidazole, de lactone macrocyclique, d'organophosphates, de salicylanilide ou de phénol substitué, de tétramisole ou de pyrimidine, agent dispersé dans un milieu dont les caractéristiques de solubilité sont telles qu'elles assurent, après administrtion orale, que des quantités modulées de cet agent anti-parasitaire atteignent le parasite, directement ou par absorption dans le plasma sanguin du ruminant, pendant le passage de cette composition par la panse, la caillette et l'intestin.

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