C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A01N 43/90 (2006.01) A61K 31/5365 (2006.01) A61P 33/10 (2006.01)
Patent
CA 2515343
The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation. More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5- (1~methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)- 6~chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3- c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.
La présente invention concerne de nouveaux terpènes alcaloïdes et leur utilisation en tant qu'agents antiparasitiques. La présente invention concerne également un agent antiparasitique qui comprend un composé de terpène alcaloïde selon l'invention en tant que principe actif dans une préparation antiparasitique. Plus particulièrement, la présente invention concerne des dérivés du terpène alcaloïde (1S,2R,4aS,5R,8R,8aR)-2-(acétyloxy)-8a-hydroxy-3,8-diméthyl-5-(1-méthyléthényl)-1,2,4a,5,6,7,8,8a-octahydronaphtalèn-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-méthyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. L'invention concerne également des compositions pharmaceutiques les comprenant.
Chubb Nathan Anthony Logan
Critcher Douglas James
Eshelby James John
Lunn Graham
Rudge Andrew John
Pfizer Inc.
Torys Llp
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