Antipicornaviral compounds and compositions, their...

Details Antipicornaviral compounds and compositions, their... Antipicornaviral compounds and compositions, their...

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/06 (2006.01) A61P 31/14 (2006.01) C07D 207/26 (2006.01) C07D 417/06 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380647

Compounds of formula (I) where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

Cette invention concerne des composés représentés par la formule (I) dont les variables sont telles que définies dans le descriptif de l'invention. Ces composés offrent l'avantage d'inhiber ou de bloquer l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que les compositions pharmaceutiques qui les renferment, conviennent pour le traitement de patients ou d'hôtes infectés par un ou plusieurs picornavirus tels que des protéases 3C à rhinovirus. Sont également décrit des produits intermédiaires ainsi que des méthodes synthétiques de fabrication de tels composés.

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