Antipicornaviral compounds and compositions, their...

Details Antipicornaviral compounds and compositions, their... Antipicornaviral compounds and compositions, their...

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) A61K 31/40 (2006.01) C07C 237/16 (2006.01) C07C 237/22 (2006.01) C07C 275/16 (2006.01) C07D 207/00 (2006.01) C07D 209/42 (2006.01) C07D 213/00 (2006.01) C07D 215/48 (2006.01) C07D 231/14 (2006.01) C07D 241/44 (2006.01) C07D 249/06 (2006.01) C07D 317/00 (2006.01) C07D 333/70 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2412618

Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

L'invention concerne des composés représentés par la formule (I) dans laquelle les variables sont telles que définies dans le descriptif, qui inhibent ou bloquent avantageusement l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que des compositions pharmaceutiques contenant ceux-ci, sont utiles pour traiter des patients ou des hôtes infectés par un ou plusieurs picornavirus, p. ex. RVP. L'invention concerne aussi des produits intermédiaires et des procédés de synthèse pour préparer ces composés.

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