C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/027 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 38/05 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 261/18 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2326763
Peptido and peptidomimetic compounds of formula (I) wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
L'invention concerne des composés peptidiques et peptidomimétiques de formule (I), dans laquelle les variables ont la définition donnée dans la description. Ces composés inhibent ou bloquent de façon avantageuse l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que des compositions pharmaceutiques les renfermant, servent à traiter des patients ou des hôtes infectés avec un ou plusieurs picornavirus, tel que les RVP. L'invention concerne également des intermédiaires et des méthodes de synthèse pour préparer lesdits composés.
Dragovich Peter Scott
Johnson Theodore O. Jr.
Marakovits Joseph Timothy
Prins Thomas Jay
Tikhe Jayashree Girish
Agouron Pharmaceuticals Inc.
Sim & Mcburney
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