C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/34 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/4025 (2006.01) A61K 38/05 (2006.01) C07D 207/26 (2006.01) C07D 207/32 (2006.01) C07D 207/333 (2006.01) C07D 401/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2406475
Compounds of the formula (I) where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
La présente invention concerne des composés représentés par la formule (I) dans laquelle les variables sont telles que définies dans la description. Ces composés inhibent ou bloquent avantageusement l'activité biologique de la protéase 3C des picornavirus. Ces composés, ainsi que des compositions pharmaceutiques contenant ces composés, conviennent particulièrement pour le traitement de patients d'hôtes infectés par un ou plusieurs picornavirus, tels que les protéases 3C de rhinovirus (RVP). L'invention concerne également des intermédiaires et des techniques de synthèse permettant de préparer de tels composés.
Dragovich Peter S.
Hua Ye
Johnson Theodore O. Jr.
Luu Hiep T.
Agouron Pharmaceuticals Inc.
Smart & Biggar
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