Antipicornaviral compounds and compositions, their...

Details Antipicornaviral compounds and compositions, their... Antipicornaviral compounds and compositions, their...

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2392504

Compounds of formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of formula (II) where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

Cette invention concerne des composés représentés par la formule (I) dont les variables sont telles que définies dans le descriptif de l'invention. Ces composés offrent l'avantage d'inhiber ou de bloquer l'activité biologique de la protéase 3C picornavirale. En outre, cette invention concerne des composés représentés par la formule (II), dont les variables sont telles que définies dans le descriptif de l'invention. Ces composés offrent l'avantage d'inhiber ou de bloquer l'activité biologique de la protéase 3C picornavirale. Ces composés, ainsi que les compositions pharmaceutiques qui les renferment, conviennent pour le traitement de patients ou d'hôtes infectés par un ou plusieurs picornavirus, tels que des protéases 3C à rhinovirus. Sont également décrit des produits intermédiaires ainsi que des méthodes synthétiques de fabrication de tels composés.

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