Antipicornaviral compounds and methods for their use and...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 5/027 (2006.01) A61K 31/27 (2006.01) A61K 31/415 (2006.01) A61K 38/05 (2006.01) C07C 271/22 (2006.01) C07D 233/70 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2312940

Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.

L'invention concerne des inhibiteurs des protéases 3C picornavirales, obtenus par synthèse chimique et qui inhibent ou bloquent l'activité biologique de ces protéases 3C picornavirales. Ces composés, de même que les compositions pharmaceutiques qui les contiennent sont conçus pour traiter des patients ou des hôtes infectés par un ou plusieurs picornavirus. L'invention concerne encore l'utilisation de plusieurs nouveaux procédés et intermédiaires dans la préparation de ces nouveaux inhibiteurs des protéases 3C picornavirales.

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