Antiprogestins with partial agonist activity

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/57 (2006.01) A61K 31/573 (2006.01) A61P 15/04 (2006.01) A61P 15/18 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2404172

The present invention features methods of inhibiting progestin activity in a cell or in a subject in need of such inhibition, and methods of treating or preventing progestin-dependent conditions in a subject in need of such treatment or prevention. The methods include administering an effective amount of a C-17-derivatized dexamethasone antiprogestin to the cell or the subject. The invention also provides methods of screening substances for progestin or antiprogestin activity, and methods of detecting progestins, progestin agonists, or antiprogestins in a sample, using the C-17-derivatized dexamethasone antiprogestins of the invention.

L'invention concerne des procédés pour inhiber l'activité de la progestine dans une cellule ou chez un sujet nécessitant cette inhibition ainsi que des procédés pour traiter ou prévenir les états dépendants de la progestine chez un sujet ne nécessitant pas ce traitement ou la prévention. Les procédés consistent à administrer à la cellule ou au sujet une quantité efficace d'antiprogestine dexaméthasone dérivée de C-17. L'invention concerne aussi des procédés pour cribler les substances à des fins de détection d'une activité de progestine ou d'antiprogestine ainsi que des procédés pour détecter des progestines, des agonistes des progestines ou des antiprogestines dans un échantillon en utilisant les antiprogestines dexaméthasones dérivées de C-17 que décrit l'invention.

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