Antiproliferation factor

Details Antiproliferation factor Antiproliferation factor

C - Chemistry, Metallurgy

07

K

530/13, 167/139,

C07K 16/22 (2006.01) C07K 14/475 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2009511

ABSTRACT Mammalian pituitary tissues contain newly discovered anti-proliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neutral cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8.1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancel cells and autoimmune diseases.

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