Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives

Details Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/41 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07D 277/42 (2006.01) C07D 277/52 (2006.01)

Patent

CA 2515728

Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

L'invention concerne des composés aminothiazole substitués avec des groupes contenant du soufre et représentés par la formule (I), ainsi que leurs sels pharmaceutiquement acceptables, des promédicaments, des métabolites actifs et les sels pharmaceutiquement acceptables de ces métabolites. Ces agents modulent et/ou inhibent la prolifération cellulaire et l'activité des protéines kinases, et sont utiles comme agents pharmaceutiques destinés au traitement de tumeurs malignes et d'autres affections.

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