C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A01N 43/04 (2006.01) A61K 31/136 (2006.01) A61K 31/337 (2006.01) A61K 31/475 (2006.01) A61K 31/513 (2006.01) A61K 31/522 (2006.01) A61K 31/573 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61K 31/711 (2006.01) A61K 33/24 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07H 21/04 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2370000
The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.
La présente invention concerne un procédé qui inhibe la prolifération de cellules malignes et/ou hyperplasiques chez un sujet, et s'effectue par administration audit sujet d'une quantité thérapeutiquement effective d'un oligonucléotide riche en guanosine. L'invention concerne également des oligonucléotides qui se lie spécifiquement à une protéine cellulaire spécifique, la nucléoline, et/ou est apparentée à la nucléoline, ladite protéine intervenant dans la prolifération de cellules, notamment de cellules malignes et/ou hyperplasiques. L'invention concerne en outre un procédé de sélection desdits oligonucléotides.
Bates Paula J.
Miller Donald M.
Trent John O.
Antisoma Research Limited
Macpherson Leslie & Tyerman Llp
Uab Research Foundation
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