Antiproliferative quinazolines

Details Antiproliferative quinazolines Antiproliferative quinazolines

C - Chemistry, Metallurgy

07

D

C07D 401/00 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 239/88 (2006.01) C07D 239/90 (2006.01) C07D 239/93 (2006.01) C07D 239/95 (2006.01) C07D 401/12 (2006.01) C07D 403/00 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01)

Patent

CA 2132514

Quinazoline compounds of Formula I which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.

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