Antiprotozoal histone acetyl transferase inhibitors

Details Antiprotozoal histone acetyl transferase inhibitors Antiprotozoal histone acetyl transferase inhibitors

C - Chemistry, Metallurgy

12

Q

C12Q 1/34 (2006.01) A01N 43/02 (2006.01) C12N 9/14 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2386299

Histone acetyl transferase inhibition provides a target for identifying potential antiprotozoal compounds. Histone acetyl transferase inhibitors are useful as therapeutic agents against protozoal infections. A method of identifying histone acetyl transferase inhibitors compares i) the acetylation level from a combination of a test compound with a known histone deacetylase inhibitor to ii) a basal acetylation level.

Selon l'invention, l'inhibition de l'histone acétyle transférase offre une cible permettant d'identifier des composés antiprotozoaires potentiels. Les inhibiteurs d'histone acétyle transférase antiprotozoaires sont utiles comme agents thérapeutiques contre les infections causées par des protozoaires. Un procédé permettant d'identifier des inhibiteurs d'histone acétyle transférase compare i) le niveau d'acétylation d'une combinaison d'un composé test avec un inhibiteur d'histone désacétylase à ii) un niveau de base d'acétylation.

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