Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)...

Details Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)... Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)...

C - Chemistry, Metallurgy

07

D

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C07D 403/04 (2006.01) C07D 239/42 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 1256871

Abstract of the Disclosure Disubstitued N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents.

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