Antipsychotic benzimidazole derivatives

Details Antipsychotic benzimidazole derivatives Antipsychotic benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 235/14 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2159220

A class of benzimidazole derivatives, substituted at the 2-position by a substituted piperazinylmethyl or pirerazinylethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.

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