Antipsychotic fused-ring pyridinylpiperazine derivatives

Details Antipsychotic fused-ring pyridinylpiperazine derivatives Antipsychotic fused-ring pyridinylpiperazine derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/246

C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1278792

ANTIPSYCHOTIC FUSED-RING PYRIDINYLPIPERAZINE DERIVATIVES Abstract of the Disclosuse Disubstituted 1,4-piperazinyl derivatives, of the formula Image wherein Z, R1, X, Y, N and R2 are as defined herein, wherein one substituent is a bicyclic fused-ring furo-, pyrrolo-, cyclopentadieno-, or thieno-pyridine heterocyclic system and the second substituent is an alkylene chain attached to cyclic imide heterocycles, such as azaspiro[4.5]decanediones, dialkylglutarimides, thiazolidinediones, succinimides, and morpholine-2,6- diones; or a benzyloic carbinol moiety. These compounds have potent antipsychotic and serotonin antagonist activities. 4-[4-[4-(4-Furo[3, 2-?]pyridinyl)-1- piperazinyll-butyl]-3,5-morpholinedione is an example of a typical embodiment having selective antipsychotic activity.

503794

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