Antisecretory branched chain heterocyclic derivatives,...

Details Antisecretory branched chain heterocyclic derivatives,... Antisecretory branched chain heterocyclic derivatives,...

C - Chemistry, Metallurgy

07

D

260/300, 260/308

C07D 417/12 (2006.01) C07D 209/48 (2006.01) C07D 277/14 (2006.01) C07D 277/48 (2006.01)

Patent

CA 1140925

ABSTRACT OF THE DISCLOSURE The invention relates to a heterocyclic derivative of tho formula: Image I in which D io O, S or NH; E is CH or when D io O or S, E is N; Y is S, O, CH2, SO or a direct bond: P is a direct bond or C(1-4)unbranched alkylene optionally substituted by 1 or 2 C(1-4)alkyls and Q is C(1-4)unbranched alkylene optionally sub- stituted by 1 or 2 C(1-4)alkyls, provided total number of alkyls in F and Q is 1 or 2, that when Y is S, O or SO, P is alkylene and that when Y is O or SO, Q is C(2-4)alkylene; R1 is H or C(1-10)alkyl; A is 3,4-dioxocyclobuten-1,2-diyl or C=Z where Z is S, O, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR2, NCO2R2, NSO2R2 or NR3 where R3 is C(1-6)alkyl or C(6-12)- aryl and R3 is H or C(1-6)alkyl: B is C(1-6)alkoxy, C(1-6)alkyl- thio or NR4R5 where R4 and R5 are H, C(1-10)alkyl, C(3-6)alkenyl, C(3-6)alkynyl, C(2-6)(primary OH)alkyl, C(2-6)(primary NH2)- alkyl, C(3-6)cycloalkyl, or R4 and R5 together are 5- or 6- membered satured ring which may contain an additional O or NH; and the salts thereof. The compounds of the invention are histamine H-2 antagonists which inhibit gastric acid secretion. The compounds are particularly distinguished by the presence of branching in the side-chain together with a pendant guadidino group.

337641

Affiliated with

Also associated with

Rating

Antisecretory branched chain heterocyclic derivatives,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisecretory branched chain heterocyclic derivatives,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisecretory branched chain heterocyclic derivatives,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-994927