Antisecretory factor peptides regulating pathological...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/16 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A23K 1/16 (2006.01) A23K 1/165 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2230111

A new recombinant protein called Antisecretory Factor (rAF) and homologues and peptide fragments thereof are described. The protein and the homologues and fragments thereof are useful for normalising pathological fluid transport and/or inflammatory reactions in animals including humans. Antibodies against AF or homologues or fragments thereof are described. Nucleic acids coding for the protein or for homologues or fragments thereof are also described as well as vectors and hosts comprising the nucleic acids. The rAF and homologues and fragments thereof could be used for immunodetection, as feed additive for growing animals and as antidiarrheal and drugs against diseases involving edema, dehydration and/or inflammation.

Nouvelle protéine recombinante dénommée Facteur Antisécrétoire (rAF), ainsi que ses homologues et fragments de peptides. Cette protéine, ses homologues et ses fragments sont utiles pour normaliser la circulation pathologique de liquide et/ou les réactions inflammatoires chez l'animal et l'homme. L'invention concerne également des anticorps contre AR ou ses homologues ou ses fragments. Elle concerne encore des acides nucléiques codant pour la protéine ou pour ses homologues ou ses fragments, ainsi que des vecteurs et hôtes comprenant ces acides nucléiques. On pourrait utiliser rAF, ses homologues ou ses fragments pour effectuer une immunodétection, en tant qu'additifs alimentaires dans l'élevage animal, ainsi qu'en tant qu'antidiarrhéique et médicaments contre des maladies, telles que l'oedème, la déshydratation et/ou l'inflammation.

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