Antisecretory guanidine derivatives, processes for their...

Details Antisecretory guanidine derivatives, processes for their... Antisecretory guanidine derivatives, processes for their...

C - Chemistry, Metallurgy

07

D

260/301, 260/302

C07D 277/48 (2006.01) C07D 233/88 (2006.01) C07D 263/48 (2006.01) C07D 271/07 (2006.01) C07D 285/08 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1127649

ABSTRACT OF THE DISCLOSURE Heterocyclic guanidine derivatives are provided which are histamine H-2 antagonists and which inhibit gastric acid secretions. Histamine H-2 receptor antagonists are de- scribed in the prior art which comprise carbon and carbon- sulfur chains having incorporated in a middle portion one or two guanidine residues with both ends of the chain being attached to heterocyclic ring systems. The present invention provides a molecular structure where the guanidino radical is directly attached to one or both of the heterocyclic ring systems. This results in a histamine H-2 antagonist of increased potency.

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