Antisecretory oxadiazole derivatives, processes for their...

Details Antisecretory oxadiazole derivatives, processes for their... Antisecretory oxadiazole derivatives, processes for their...

C - Chemistry, Metallurgy

07

D

260/310.7

C07D 271/06 (2006.01) C07D 271/07 (2006.01)

Patent

CA 1125296

ABSTRACT The invention relates to oxadiazole derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manuracture and to pharma- ceutical compositions containing them. The oxadiazole derivatives are of the formula :- Image I in which Y is O, S, CH2 or a direct bond, m is O to 4 and n is 1 to 4, provided that when Y is S or O m is 1 to 4 and when Y is.O n is 2 to 4; A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR , NCO2R , NSO2R or NR in which- R1 is alkyl or aryl and R2 is H or alkyl;B is alkoxy or alkylthio or NHR3 in which R3 is H or alkyl: and the salts thereof.

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