Antisecretory thiadiazole derivatives, processes for their...

Details Antisecretory thiadiazole derivatives, processes for their... Antisecretory thiadiazole derivatives, processes for their...

C - Chemistry, Metallurgy

07

D

260/301, 260/308

C07D 417/12 (2006.01) C07D 285/08 (2006.01)

Patent

CA 1124729

ABSTRACT OF THE INVENTION The invention relates to a thiadiazole derivative of the formula I: Image in which Y is O, S, CH2, 50 or a direct bond; m is 0 to 4 and n is 1 to 4 provided that when Y is S, O or SO m is 1 to 4, and when Y is O or SO n is 2 to 4; R is H or (Cl-lO)alkyl; A is 3,4-dioxocyclobuten-1,2-diyl or C=Z in which Z is ), 5, NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR2, NCO2R2, NSO2R2, or NR3 in which R2 is (cl-6)alkYl or (C6-12)arYl and R3 is H or (Cl-6)alkyls B is (Cl-6)alkoXY, (Cl-6)alkYlthio or NR4R5 in whtch R4 and R5 are independently H, (Cl-l0)alkyl, C3-6(alkenyl), (C3-6)alkynyl, (C2-6)(primary hydroxy)alkyl, (C2-6)(primary amino) alkyl or (C3-6)cycloalkyl or R4 andR5 arejoined to form a 5- or 6-membered saturated ring optionally containing an additional O or NH: and the salts thereof. The compounds of the invention are histamine H-2 antagonists ana which lnhibit gastric acid secretion.

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