C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2300938
The present invention is directed to novel nucleic acid molecules and methods for their use. More specifically, the novel nucleic acid molecules of the present invention are capable of tightly and specifically interacting with a target molecule of interest not only through standard Watson-Crick base pairing, but also through additional fetaures which allow the antisense molecules to become topologically "locked" onto the target nucleic acid, thereby imparting improved transcription and translation inhibitory properties.
L'invention concerne des nouvelles molécules d'acide nucléique et leurs méthodes d'utilisation. Les nouvelles molécules d'acide nucléique de l'invention sont, plus spécifiquement, capables d'interagir étroitement et spécifiquement avec une molécule cible à analyser non seulement par l'appariement des bases de Watson Crick standard, mais également par des caractéristiques supplémentaires qui permettent aux molécules antisens d'être "bloquées" sur le plan topologique sur l'acide nucléique cible, ce qui confère des propriétés d'inhibition de la transcription et de la traduction améliorées.
Johnston Brian H.
Kazakov Sergei A.
Kisich Kevin O.
Smart & Biggar
Somagenics Inc.
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