A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/712 (2006.01) A61K 31/5377 (2006.01) A61K 31/675 (2006.01) A61K 31/7064 (2006.01) A61P 31/14 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2463641
This invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.
L'invention porte sur des composés antiviraux antisens et sur leurs procédés d'utilisation dans l'inhibition de la croissance des virus des familles de picornavirus, calicivirus, togavirus et flavivirus ainsi que dans le traitement d'une infection virale. Les composés antiviraux antisens sont des oligomères pratiquement non chargés ayant une séquence de bases de ciblage pratiquement complémentaire d'une séquence virale cible qui englobe le site de démarrage de la transcription AUG de la première phase de lecture ouverte du génome viral.
Iversen Patrick L.
Skilling Douglas E.
Smith Alvin W.
Stein David A.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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