C - Chemistry – Metallurgy – 08 – F
Patent
C - Chemistry, Metallurgy
08
F
C08F 130/02 (2006.01) A61P 31/14 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2522508
The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus, coronavirus, and flavivirus families, as in treatment of a viral infection. In particular embodiments, the virus is an RNA virus from the coronavirus family or a West Nile, Yellow Fever or Dengue virus from the flavivirus family. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.
L'invention concerne des composés antiviraux antisens et des procédés d'utilisation de ces composés pour inhiber la croissance de virus de la famille des picornavirus, calicivirus, togavirus, coronavirus et flavivirus, ainsi que pour traiter une infection virale. Dans certains modes de réalisation de cette invention, le virus est un virus à ARN de la famille des coronavirus, ou le virus du Nil occidental, de la fièvre jaune ou de la dengue, qui sont issus de la famille des flavivirus. Les composés antiviraux antisens selon l'invention sont des oligomères sensiblement non chargés présentant une séquence de bases de ciblage qui est sensiblement complémentaire à une séquence virale cible laquelle englobe le site de départ AUG du premier cadre de lecture ouvert du génome viral.
Iversen Patrick L.
Skilling Douglas E.
Smith Alvin W.
Stein David A.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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