A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7125 (2006.01) C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61P 31/14 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2621964
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5' untranslated region identified by SEQ ID NO:4.
L'invention concerne des composés antisens antiviraux et leurs procédés d'utilisation et de production au niveau de l'inhibition de la croissance des virus de la famille Picornaviridae et du traitement d'une infection virale. Ces composés sont particulièrement utiles pour traiter l'infection de l'Enterovirus et/ou du Rhinovirus chez un mammifère. Les composés antisens antiviraux sont sensiblement neutres, comportant des oligonucléotides morpholino en partie chargés positivement, ont une séquence de 12-40 sous-unités, comportant au moins 12 sous-unités ayant une séquence cible complémentaire d'une zone associée à des séquences ARN virales à l'intérieur d'une zone nucléotidique de 32 de la zone non traduite 5' identifiée par SEQ ID NO:4.
Iversen Patrick L.
Rijnbrand Cornelis A.
Stein David A.
Weller Dwight D.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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