C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01N 43/04 (2006.01) A61K 31/07 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2644262
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Arenaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Arenavirus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 19 nucleotide region of the 5'-terminal regions of the viral RNA, viral complementary RNA and/or mRNA identified by SEQ ID NO:1.
L'invention concerne des composés antiviraux antisens et leurs procédés d'utilisation et de production dans l'inhibition de la croissance de virus de la famille Arenaviridae et dans le traitement d'une infection virale. Les composés sont particulièrement utiles dans le traitement de l'infection par Arenavirus chez un mammifère. Les composés antiviraux antisens sont essentiellement des oligonucléotides morpholino non chargés, ont une séquence de 12 à 40 sous-unités, incluant au moins 12 sous-unités ayant une séquence cible complémentaire à une région associée à des séquences d'ARN viral au sein d'une région de 19 nucléotides des régions terminales en 5'-de l'ARN viral, de l'ARN viral complémentaire et/ou de l'ARNm identifié par la SEQ ID NO:1.
Buchmeier Michael
Iversen Patrick L.
Neuman Benjamin
Stein David A.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
The Scripps Research Institute
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