C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01)
Patent
CA 2584599
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having 1) a nuclease resistant backbone, 2) 12-40 nucleotide bases, and 3) a targeting sequence of at least 12 bases in length that hybridizes to a target region selected from the following: a) the 5' or 3' terminal 25 bases of the negative sense viral RNA segment of Influenzavirus A, Influenzavirus B and Influenzavirus C; b) the terminal 25 bases of the 3' terminus of the positive sense cRNA and; and c) the 50 bases surrounding the AUG start codon of an influenza viral mRNA.
L'invention porte sur des composés antiviraux antisens et leurs procédés de production et d'utilisation pour inhiber la croissance de virus de la famille des Orthomyxoviridae et traiter les infections virales, lesdits composés s'avérant spécialement utiles dans le traitement des infections virales chez les mammifères. Ces composés sont des morpholino oligonucléotides quasiment non modifiés comprenant: 1) un squelette résistant à la nucléase, 2) 12 à 40 bases de nucléotides, et 3) une séquence de ciblage d'au moins 12 bases de longueur s'hybridant à une région cible sélectionnée parmi: a) les 25 bases terminales 5' ou 3' du segment de sens négatif de l'ARN des virus A, B et C de la grippe; b) les 25 bases terminales du terminus 3' de l'ARNc de sens positif; et c) les 50 bases entourant le codon de départ AUG de l'ARNm du virus de la grippe.
Chen Jianzhu
Ge Qing
Iversen Patrick L.
Stein David A.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
Massachusetts Institute Of Technology
LandOfFree
Antisense antiviral compound and method for treating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antisense antiviral compound and method for treating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense antiviral compound and method for treating... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2015306